ea0041gp118 | Endocrine Tumours | ECE2016
Verdelli Chiara
, Forno Irene
, Ferrero Stefano
, Guarnieri Vito
, Scillitani Alfredo
, Cetani Filomena
, Vicentini Leonardo
, Balza Gianni
, Beretta Edoardo
, Creo Pasquale
, Vaira Valentina
, Corbetta Sabrina
An embryonic gene signature has been suggested in parathyroid tumours. We investigated the expression of early embryonic stem cell (ESC) genes in parathyroid tumours. POU5F1/OCT4, SOX2 and NANOG transcripts were detected in almost all parathyroid adenomas (PAds; n=22) and atypical PAds (n=3), besides the variable expression of ESC genes KLF4, EGR1, and REX1/ZFP42. OCT4, SOX2 and NANOG proteins expression w...